AGOMELATINE AGOMELATINE AGOMELATINE AGOMELATINE AGOMELATINE CAS 138112-76-2

Model: qqbio081b
Place of Origin: Hebei,China (Mainland)
Purity: 99%: color:: white and yellow
package: 10g/bag: delivery: express
usage: research: Packing:10g/bag

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:10.0 USDProduction Capacity:1000kg
Trade Term:FOB,CFR,CIFPacking:Aluminum foil bag
Payment Terms:L/C, WU, Money Gram, T/T, PaypalDelivery Date:within 24 hours
Min. Order:10 Gram
Means of Transport:Land, Ocean, Air

Model No:138112-76-2
Place of Origin:Hebei,China (Mainland)
Brand Name:qianqiu
CAS No.:138112-76-2
Purity:99%min
Formula:C15H17NO2
M.Wt:243.4 °C
Min Order:1g


Chemical Properties

Cas No.138112-76-2
Chemical NameN-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
Canonical SMILESCC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC
FormulaC15H17NO2M.Wt243.3
SolubilitySoluble in DMSO > 10 mMStorageStore at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].

Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].

We could give you:

1. Best quality in your requirement

2. Competitive price in China market

3. mature Technical support

4. Professional logistic support

5 . Full experience of large numbers containers loading in Chinese sea port

6 Fast shipment by reputed shipping line

7. Packing with pallet as buyer's special request

8. Best service after shipment with e mail

9. Cargoes together with container after-sales service available

10. Full experience in export

11. Raw materials from Chinese origin

All we want is win-win business. Send yr. inquiries, you will get it!


Model No:138112-76-2
Place of Origin:Hebei,China (Mainland)
Brand Name:qianqiu
CAS No.:138112-76-2
Purity:99%min
Formula:C15H17NO2
M.Wt:243.4 °C
Min Order:1g


Chemical Properties

Cas No.138112-76-2
Chemical NameN-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
Canonical SMILESCC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC
FormulaC15H17NO2M.Wt243.3
SolubilitySoluble in DMSO > 10 mMStorageStore at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].

Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].

We could give you:

1. Best quality in your requirement

2. Competitive price in China market

3. mature Technical support

4. Professional logistic support

5 . Full experience of large numbers containers loading in Chinese sea port

6 Fast shipment by reputed shipping line

7. Packing with pallet as buyer's special request

8. Best service after shipment with e mail

9. Cargoes together with container after-sales service available

10. Full experience in export

11. Raw materials from Chinese origin

All we want is win-win business. Send yr. inquiries, you will get it!


Category: research pharmaceutical intermediates chemical pharmatical


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